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Oral_BA Oral_BA

Technical Overview Technical Overview

The technology improves the drug solubility and bioavailability of an insoluble drug a by preparing a solid dispersion with a solubilizing polymer.

Crystalline drug + solubilized polymer

Characteristics Characteristics

  • Excellent solubilization effect
  • Incredibly effective improvement of bioavailability
  • Applicability to various drugs
  • Applied product: SYO-1644

Oral_FDT Oral_FDT

Technical Overview Technical Overview

  • Highly plastic granules are prepared by wet granulation using porous materials, water penetration enhancers and binders and compressed at low pressure to obtain Frosta® fast dissolving tablets (FDT). FDT is rapidly disintegrated by saliva on the tongue and can be taken without water.
  • FDT is a technology developed in collaboration with Akina, USA.
  • Applicable to sustained release, and enteric coated microparticle products.
Oral_FDT Image

Characteristics Characteristics

  • Outstanding physical strength (high hardness and low wear loss)
  • Masks bitter taste
  • Suitable for : pediatric, elderly, patients who have difficulty in swallowing tablets, patients with limited water intake, travelers, and lay patients, etc.
  • Applied product : Emestop oral disintegrating tablet


Technical Overview Technical Overview

CSDS is a drug delivery technology in which tablets are coated with a special coating that is disintegrated by bacteria in the intestines. The drug is specifically released only when it reaches the large intestine. Unlike the commonly used pH dependent colonic transporter or time dependent system, it can deliver the drug to the large intestine with low individual variability.

Oral_CSDS 이미지

Characteristics Characteristics

  • Reduced side effects and improved stability due to the specific drug release in the large intestine
  • Applicable to peptide drugs
  • Applied product : Prednisolone CSDS

Biodegradable Polymer Biodegradable Polymer

Medical aliphatic polyester based biodegradable polymers and bio-implantable devices that are degraded and absorbed in the body after a certain period of time after surgery are in development.

Samyang Holdings Biopharmaceuticals Division aims to generate various biodegradable polymers with different strengths and degradation periods. The major technology synthesizes polymers from lactone monomers (glycolide, lactide, p-dioxanone, etc.) with various composition and uniform molecular weights. High strength surgical sutures, surgical meshes, orthopedic implants, and bioabsorbable stents can be manufactured through precision application processing of the polymer.

In particular, Samyang Holdings Biopharmaceuticals Division has the capability to synthesize polymers with an ultra-high molecular weight (UHMW), which can be used as the base material of high-strength biodegradable surgical devices.

Cyclic ester monomer Medical biodegradable polyester utilizing product